Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | USP5 | P45974 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30636803 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL9984386 | 0.79 | KDM4E (0.65) | KDM4EHSD17B10HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL16586809 | 0.77 | KDM4E (0.63) | KDM4EHSD17B10HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL24663283 | 0.76 | KDM4E (0.61) | KDM4EHSD17B10HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL11924611 | 0.76 | KDM4E (0.61) | KDM4EHSD17B10HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL31103501 | 0.76 | KDM4E (0.61) | KDM4EHSD17B10HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL10967918 | 0.75 | KDM4E (0.60) | KDM4EHSD17B10HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL10969790 | 0.72 | KDM4E (0.57) | KDM4EHSD17B10HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL12145661 | 0.72 | KDM4E (0.57) | KDM4EHSD17B10HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL7330343 | 0.72 | KDM4E (0.57) | KDM4EHSD17B10HPGDSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008122038-A1 | REGULATING AUTOPHAGY | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2008-10-09 | — | — | WO | disclosed |