Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9984386 | 0.75 | KDM4E (0.65) | KDM4EHPGDHSD17B10KMT2ARAB9A | |
| SCHEMBL16586809 | 0.74 | KDM4E (0.63) | KDM4EHPGDHSD17B10KMT2ARAB9A | |
| SCHEMBL30636803 | 0.72 | KDM4E (1.00) | KDM4EHPGDHSD17B10KMT2ARAB9A | |
| SCHEMBL4787828 | 0.72 | KDM4E (1.00) | KDM4EHPGDHSD17B10KMT2ARAB9A | |
| SCHEMBL12145661 | 0.72 | KDM4E (0.57) | KDM4EHPGDHSD17B10KMT2ARAB9A | |
| SCHEMBL30394105 | 0.69 | RAB9A (0.56) | KDM4EHPGDHSD17B10KMT2ARAB9A | |
| SCHEMBL12145708 | 0.68 | KDM4E (0.48) | KDM4EHPGDHSD17B10KMT2ARAB9A | |
| SCHEMBL12145679 | 0.68 | KDM4E (0.55) | KDM4EHPGDHSD17B10KMT2ARAB9A | |
| SCHEMBL13259156 | 0.68 | HSD17B10 (0.51) | KDM4EHPGDHSD17B10KMT2ARAB9A | |
| SCHEMBL14815362 | 0.68 | KDM4E (0.55) | KDM4EHPGDHSD17B10KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417027-A1 | Tetracyclic imidazoquinazoline derivatives, process for their preparation and pharmaceutical compositions containing them | NOVO NORDISK A/S (DK) | 1991-03-13 | — | — | EP | disclosed |