SCHEMBL4787982

SCHEMBL4787982

COC(=O)C1CCCCN1Cc1ccc(OCc2coc(-c3ccc(C(F)(F)F)cc3)n2)cc1

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.54
KDM4E B2RXH2 1/20 0.54
PPARG P37231 5/20 0.48
PPARA Q07869 5/20 0.48
SPHK2 Q9NRA0 1/20 0.43
SPHK1 Q9NYA1 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
HRH3 Q9Y5N1 1/20 0.42
CD274 Q9NZQ7 2/20 0.42
FFAR1 O14842 1/20 0.42
SLC6A5 Q9Y345 3/20 0.42
SCN9A Q15858 1/20 0.41
SMPD1 P17405 1/20 0.41
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41
PTGER4 P35408 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4748393 0.98 KDM4E (0.50) ALDH1A1KDM4EPPARGPPARASPHK2
SCHEMBL4746603 0.92 ALDH1A1 (0.52) ALDH1A1KDM4EPPARGPPARASPHK2
SCHEMBL4747149 0.91 KDM4E (0.49) ALDH1A1KDM4EPPARGPPARASPHK2
SCHEMBL4748089 0.91 PPARA (0.58) ALDH1A1KDM4EPPARGPPARASMN1; SMN2
SCHEMBL4746190 0.90 PPARG (0.51) ALDH1A1KDM4EPPARGPPARASPHK2
SCHEMBL4747971 0.89 HRH3 (0.47) ALDH1A1KDM4EPPARGPPARASPHK2
SCHEMBL4747069 0.89 HRH3 (0.47) ALDH1A1KDM4EPPARGPPARASPHK2
SCHEMBL4747119 0.88 PPARA (0.59) ALDH1A1KDM4EPPARGPPARASPHK1
SCHEMBL4746563 0.87 FFAR1 (0.55) ALDH1A1PPARGPPARASPHK1CD274
SCHEMBL4744142 0.83 PPARG (0.52) ALDH1A1KDM4EPPARGPPARASPHK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008117982-A1 HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR INHIBITING LIPID ACCUMULATION CONTAINING SAME CRYSTAL GENOMICS, INC. (KR) 2008-10-02 WO disclosed