Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.34 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | USP7 | Q93009 | 2/20 | 0.33 |
| ▸ | WDR5 | P61964 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788571 | 0.87 | CYP19A1 (0.46) | CYP19A1ADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL4749208 | 0.85 | FFAR1 (0.38) | MAOBSLC6A2SLC6A4GRM5SLC6A3 | |
| SCHEMBL4788602 | 0.84 | NISCH (0.44) | MAOBADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL4746486 | 0.83 | ADRA2A (0.42) | HTR1BADRA2AADRA2BADRA2CALDH1A1 | |
| Hydrochloric Acid SCHEMBL4749089 | 0.81 | ADRA2A (0.41) | HTR1BADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL4786568 | 0.81 | HTR1B (0.49) | MAOBSLC6A2SLC6A4HTR1BSLC6A3 | |
| SCHEMBL4787640 | 0.81 | HTR1B (0.39) | MAOBSLC6A4HTR1BCYP19A1ADRA2A | |
| SCHEMBL4788401 | 0.79 | KDM4E (0.44) | MAOBADRA2AADRA2BADRA2C | |
| Acetic Acid SCHEMBL4787678 | 0.79 | MAOA (0.42) | MAOBALDH1A1 | |
| SCHEMBL14042569 | 0.77 | HTR1B (0.46) | MAOBSLC6A2SLC6A4HTR1BSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123821-A1 | 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-10-16 | — | — | WO | claimed |
| WO-2008123821-A1 | 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-10-16 | — | — | WO | disclosed |