Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30151166 | 0.87 | PIK3CA (0.44) | PIK3CAPIK3CBSMN1; SMN2PIK3CDPDE7B | |
| SCHEMBL23804721 | 0.84 | SMN1; SMN2 (0.46) | PIK3CAPIK3CBSMN1; SMN2PIK3CDPDE7B | |
| SCHEMBL994274 | 0.82 | PIK3CA (0.46) | PIK3CAPIK3CBCYP2D6PIK3CDMTOR | |
| SCHEMBL12727282 | 0.79 | PIK3CA (0.46) | PIK3CAPIK3CBSMN1; SMN2PIK3CDPARP1 | |
| SCHEMBL2674386 | 0.77 | HRH3 (0.41) | PIK3CAPIK3CBSMN1; SMN2PIK3CDPDE7B | |
| SCHEMBL13983587 | 0.77 | PIK3CD (0.49) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL12926571 | 0.77 | PIK3CA (0.45) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL4752635 | 0.76 | PIK3CA (0.42) | PIK3CAPIK3CBSMN1; SMN2PIK3CDPDE7B | |
| SCHEMBL23804692 | 0.76 | SMN1; SMN2 (0.47) | PIK3CAPIK3CBSMN1; SMN2PIK3CDPARP1 | |
| SCHEMBL189804 | 0.75 | PIK3CA (0.61) | PIK3CAPIK3CBPIK3CDMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008152394-A1 | PHARMACEUTICAL COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-12-18 | — | — | WO | disclosed |