Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 10/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.64 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.64 |
| ▸ | DRD2 | P14416 | 8/20 | 0.52 |
| ▸ | DRD4 | P21917 | 8/20 | 0.52 |
| ▸ | DRD3 | P35462 | 8/20 | 0.52 |
| ▸ | HTR2A | P28223 | 7/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788881 | 0.80 | SCN9A (0.68) | SCN9AKCNH2SCN5ARIPK1 | |
| SCHEMBL4840071 | 0.78 | KCNH2 (0.64) | SCN9AKCNH2SCN5ADRD2DRD3 | |
| SCHEMBL4840083 | 0.78 | KCNH2 (0.64) | SCN9AKCNH2SCN5ADRD2DRD3 | |
| SCHEMBL20288009 | 0.78 | SCN9A (1.00) | SCN9AKCNH2SCN5ADRD2DRD3 | |
| SCHEMBL4789431 | 0.77 | SCN9A (0.60) | SCN9AKCNH2SCN5ARIPK1 | |
| SCHEMBL4840371 | 0.77 | KCNH2 (0.62) | SCN9AKCNH2SCN5ADRD2DRD3 | |
| SCHEMBL4840362 | 0.77 | KCNH2 (0.62) | SCN9AKCNH2SCN5ADRD2DRD3 | |
| SCHEMBL4788286 | 0.76 | KCNH2 (0.67) | SCN9AKCNH2SCN5A | |
| SCHEMBL4748122 | 0.75 | SCN9A (0.65) | SCN9AKCNH2SCN5ADRD2DRD4 | |
| SCHEMBL4788603 | 0.74 | SCN9A (0.60) | SCN9AKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130321-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR 5-HETEROCYCLYL-CHROMANE OR 8-HETEROCYCLYL-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130321-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR 5-HETEROCYCLYL-CHROMANE OR 8-HETEROCYCLYL-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |