Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20877573 | 0.84 | KDM4E (0.49) | MAPTKDM4ECA12CA1CA2 | |
| SCHEMBL31443901 | 0.78 | CA12 (0.46) | MAPTKDM4ECA12CA1CA2 | |
| SCHEMBL10201433 | 0.76 | KDM4E (0.41) | KDM4EALDH1A1TP53HTTLMNA | |
| SCHEMBL21635516 | 0.74 | MAPT (0.44) | MAPTKDM4ECA12CA1CA2 | |
| SCHEMBL4788966 | 0.74 | HTR2A (0.43) | MAPTKDM4ECA12CA1CA2 | |
| SCHEMBL11317582 | 0.73 | MAPT (0.54) | MAPTKDM4EGAAALDH1A1HSD17B10 | |
| SCHEMBL9334616 | 0.73 | MAPT (0.41) | MAPTKDM4ECA12CA1CA2 | |
| SCHEMBL93915 | 0.71 | DRD2 (0.57) | MAPTKDM4EDRD2DRD4ALDH1A1 | |
| SCHEMBL15290389 | 0.71 | MAPT (0.47) | MAPTKDM4ECA12CA1CA2 | |
| SCHEMBL29358285 | 0.71 | DRD2 (0.57) | MAPTKDM4EDRD2DRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632261-B1 | INHIBITORS OF HEPATITIS C VIRUS | PRESIDIO PHARMACEUTICALS INC (US) | 2016-07-13 | — | — | EP | disclosed |
| WO-2012058125-A1 | INHIBITORS OF HEPATITIS C VIRUS | PRESIDIO PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | WO | disclosed |