Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 10/20 | 0.65 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746797 | 0.94 | LCK (0.64) | LCKKITCSF1RBRAF | |
| SCHEMBL4746517 | 0.90 | LCK (0.63) | LCKKITSRCMAPK14CSF1R | |
| SCHEMBL14042471 | 0.88 | LCK (0.65) | LCKKITSRCMAPK14CSF1R | |
| SCHEMBL4750073 | 0.87 | BRAF (0.64) | LCKKITSRCMAPK14CSF1R | |
| SCHEMBL4863711 | 0.85 | LCK (0.57) | LCKKITSRCMAPK14CSF1R | |
| SCHEMBL14042261 | 0.85 | LCK (0.57) | LCKKITSRCMAPK14CSF1R | |
| SCHEMBL14042457 | 0.85 | BRAF (0.61) | LCKKITSRCMAPK14CSF1R | |
| SCHEMBL4788996 | 0.84 | LCK (0.57) | LCKHTTKDM4EMAPTBRAF | |
| SCHEMBL14042454 | 0.84 | CSNK1D (0.66) | LCKKITSRCMAPK14CSF1R | |
| SCHEMBL14042661 | 0.84 | BRAF (0.65) | LCKKITSRCMAPK14CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124393-A1 | BENZOTHIAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-10-16 | — | — | WO | disclosed |
| WO-2008124393-A1 | BENZOTHIAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-10-16 | — | — | WO | disclosed |