Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 4/20 | 0.35 |
| ▸ | FNTB | P49356 | 4/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751578 | 0.81 | KDM4E (0.37) | KDM4EGLAATMALDH1A1HSD17B10 | |
| SCHEMBL4748837 | 0.79 | KDM4E (0.36) | KDM4EGLAATMALDH1A1HSD17B10 | |
| SCHEMBL4911915 | 0.78 | KCNH2 (0.33) | KDM4EALDH1A1GAALMNA | |
| SCHEMBL4748740 | 0.74 | KDM4E (0.39) | KDM4EATMALDH1A1HSD17B10MAPT | |
| SCHEMBL4814388 | 0.70 | KDM4E (0.40) | KDM4EALDH1A1HSD17B10MAPTGAA | |
| SCHEMBL4751257 | 0.68 | P2RY12 (0.37) | KDM4EALDH1A1HSD17B10MAPTGAA | |
| SCHEMBL17224934 | 0.68 | CYP1A2 (0.44) | KDM4EALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL20379573 | 0.68 | MAPT (0.45) | KDM4EALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL4788781 | 0.67 | CYP1A2 (0.34) | KDM4EHTTLMNA | |
| SCHEMBL6137034 | 0.67 | CA12 (0.55) | KDM4EGLAATMALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008135824-A1 | OXYALKYLPYRAZOLE COMPOUNDS USEFUL IN THERAPY | PFIZER LIMITED (GB) | 2008-11-13 | — | — | WO | disclosed |