Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12088095 | 0.86 | TP53 (0.70) | TP53HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11349132 | 0.85 | CA1 (0.56) | TP53HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14692564 | 0.84 | ALDH1A1 (0.53) | TP53HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10983744 | 0.82 | TP53 (1.00) | TP53HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10986951 | 0.79 | TP53 (0.68) | TP53HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1753520 | 0.79 | TP53 (0.75) | TP53HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4771303 | 0.79 | HTT (1.00) | TP53HTTGAALMNAKMT2A | |
| SCHEMBL4487634 | 0.77 | KDM4E (0.72) | TP53HTTSMN1; SMN2GAAMEN1 | |
| SCHEMBL18172023 | 0.77 | MAPT (0.57) | TP53HTTHPGDGAALMNA | |
| SCHEMBL10972562 | 0.76 | TP53 (0.57) | TP53HTTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130321-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR 5-HETEROCYCLYL-CHROMANE OR 8-HETEROCYCLYL-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |