Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.56 |
| ▸ | CA2 | P00918 | 3/20 | 0.56 |
| ▸ | CA4 | P22748 | 3/20 | 0.56 |
| ▸ | CA9 | Q16790 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789300 | 0.85 | TP53 (0.69) | CA1CA2CA4CA9TP53 | |
| SCHEMBL20604184 | 0.83 | HTT (0.78) | CA1CA2CA4CA9TP53 | |
| SCHEMBL10986951 | 0.81 | TP53 (0.68) | CA2TP53ALDH1A1CYP1A2HTT | |
| SCHEMBL11333929 | 0.81 | SMN1; SMN2 (0.79) | CA1CA2CA4CA9TP53 | |
| SCHEMBL30808868 | 0.78 | HTT (0.53) | CA1CA2CA4CA9TP53 | |
| SCHEMBL27848899 | 0.77 | CA1 (0.61) | CA1CA2CA4CA9ALDH1A1 | |
| SCHEMBL31755988 | 0.76 | DCTPP1 (0.51) | CA1CA2CA4CA9TP53 | |
| SCHEMBL10983505 | 0.76 | SMN1; SMN2 (0.67) | CA1CA2CA4CA9TP53 | |
| SCHEMBL19501329 | 0.75 | CA2 (0.58) | CA1CA2CA4CA9TP53 | |
| SCHEMBL12088095 | 0.75 | TP53 (0.70) | CA1CA2CA9TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002562-B1 | TRIAZOLO-QUINOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | BEECHAM GROUP PLC (GB) | 1981-05-20 | — | — | EP | disclosed |
| EP-0002562-A1 | Triazolo-quinoline derivatives, processes for their preparation and their pharmaceutical use | BEECHAM GROUP PLC (GB) | 1979-06-27 | — | — | EP | disclosed |