Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 3/20 | 0.45 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | METAP1 | P53582 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4790525 | 0.91 | AQP1 (0.56) | AQP1EZH2SIRT2HRH4HRH3 | |
| SCHEMBL6047925 | 0.88 | AQP1 (0.44) | AQP1EZH2S1PR4SIRT2HRH4 | |
| SCHEMBL4968887 | 0.85 | AQP1 (0.41) | AQP1EZH2SIRT2HRH4HRH3 | |
| SCHEMBL5147171 | 0.84 | AQP1 (0.58) | AQP1EZH2SIRT2HRH4HRH3 | |
| SCHEMBL4220746 | 0.83 | AQP1 (0.60) | AQP1EZH2S1PR4SIRT2HRH4 | |
| SCHEMBL4831109 | 0.83 | AQP1 (0.40) | AQP1EZH2S1PR4SIRT2METAP1 | |
| SCHEMBL4231582 | 0.83 | AQP1 (0.40) | AQP1EZH2S1PR4METAP1 | |
| SCHEMBL6047924 | 0.82 | AQP1 (0.41) | AQP1EZH2S1PR4 | |
| SCHEMBL4220767 | 0.81 | AQP1 (0.64) | AQP1EZH2S1PR4HRH4HRH3 | |
| SCHEMBL4220770 | 0.81 | AQP1 (0.49) | AQP1EZH2S1PR4SIRT2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879569-A2 | THERAPEUTIC COMBINATIONS FOR THE TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERS | Wyeth (US) | 2008-01-23 | — | — | EP | claimed |
| EP-1874292-A2 | METHODS FOR MODULATING BLADDER FUNCTION | Wyeth (US) | 2008-01-09 | — | — | EP | claimed |
| WO-2006116221-A2 | THERAPEUTIC COMBINATIONS FOR THE TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERS | WYETH (US) | 2006-11-02 | — | — | WO | claimed |
| WO-2006116169-A2 | METHODS FOR MODULATING BLADDER FUNCTION | WYETH (US) | 2006-11-02 | — | — | WO | claimed |
| EP-1874292-A2 | METHODS FOR MODULATING BLADDER FUNCTION | Wyeth (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006116169-A2 | METHODS FOR MODULATING BLADDER FUNCTION | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |