Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789553 | 1.00 | CYP1A2 (0.43) | CYP1A2CYP2C9KMT2AMEN1LMNA | |
| SCHEMBL4710440 | 0.89 | KMT2A (0.40) | KMT2AMEN1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL4710439 | 0.89 | KMT2A (0.40) | KMT2AMEN1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL4710365 | 0.85 | LMNA (0.42) | CYP1A2KMT2AMEN1LMNAHPGD | |
| SCHEMBL4710366 | 0.85 | LMNA (0.42) | CYP1A2KMT2AMEN1LMNAHPGD | |
| SCHEMBL4713415 | 0.83 | RELA (0.52) | CYP1A2SMN1; SMN2RELAMAOBMAOA | |
| SCHEMBL4713419 | 0.83 | RELA (0.52) | CYP1A2SMN1; SMN2RELAMAOBMAOA | |
| SCHEMBL4712632 | 0.81 | MEN1 (0.53) | CYP1A2CYP2C9KMT2AMEN1LMNA | |
| SCHEMBL4712633 | 0.81 | MEN1 (0.53) | CYP1A2CYP2C9KMT2AMEN1LMNA | |
| SCHEMBL4711845 | 0.78 | CHAT (0.45) | CYP1A2CYP2C9KMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-A2 | PYRIDINE DERIVATIVES | Novartis AG (CH) | 2000-05-10 | — | — | EP | claimed |
| WO-1999002497-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 1999-01-21 | — | — | WO | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |