Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NNMT | P40261 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12466646 | 0.77 | MAP2K1 (0.45) | MAP2K1ATM | |
| SCHEMBL3604129 | 0.71 | SIRT3 (0.43) | NNMT | |
| SCHEMBL12466445 | 0.70 | NNMT (0.38) | NNMTAURKAPIM1 | |
| SCHEMBL31297123 | 0.68 | NTRK1 (0.46) | CSNK1A1DYRK1BBRD4ALDH1A1ATM | |
| SCHEMBL4789593 | 0.68 | HSD17B10 (0.47) | BRD4ALDH1A1ATMNNMTPARP1 | |
| SCHEMBL26110395 | 0.68 | HSD17B10 (0.44) | CSNK1A1DYRK1BBRD4ALDH1A1ATM | |
| SCHEMBL12466356 | 0.68 | PIM1 (0.39) | NNMTAURKAPIM1 | |
| SCHEMBL7394232 | 0.64 | ALDH1A1 (0.39) | MAPK8CSNK1A1LIMK1MAP2K1PRKAA1 | |
| SCHEMBL21471348 | 0.64 | PARP1 (0.53) | BRD4ALDH1A1AURKAPARP1ALOX15 | |
| SCHEMBL8362799 | 0.64 | MAPT (0.42) | ALDH1A1ATMNNMTPARP1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008148034-A1 | MAPK/ERK KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-04 | — | — | WO | claimed |
| WO-2008148034-A1 | MAPK/ERK KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-04 | — | — | WO | disclosed |