Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2978671 | 0.77 | KDR (0.40) | PIK3CAPIK3CGKDRFLT1FLT4 | |
| SCHEMBL2974547 | 0.72 | KDR (0.34) | PIK3CAPIK3CGMAPTMEN1RAB9A | |
| SCHEMBL4789878 | 0.64 | IKBKB (0.41) | IKBKBIRAK4CHEK2MEN1KMT2A | |
| SCHEMBL4481912 | 0.64 | BCAT2 (0.61) | IKBKBCHEK2MAPTRAB9ACHEK1 | |
| Hydrochloric Acid SCHEMBL27721971 | 0.62 | BCAT2 (0.59) | IKBKBCHEK2MAPTRAB9ACHEK1 | |
| SCHEMBL27955118 | 0.62 | IKBKB (0.51) | IKBKBIRAK4CHEK2MAPTFLT4 | |
| SCHEMBL252954 | 0.62 | IKBKB (0.39) | IKBKBIRAK4CHEK2MAPTKDR | |
| SCHEMBL3125643 | 0.61 | IKBKB (0.55) | IKBKBJAK2PIM1 | |
| SCHEMBL2066159 | 0.60 | RBP4 (0.44) | MAPTKDRALDH1A1AURKAJAK2 | |
| SCHEMBL16837093 | 0.60 | PIM1 (0.46) | IRAK4PIK3CAMAPTKDRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945220-A1 | PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS CANNABINOID RECEPTOR ANTAGONISTS | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007046548-A1 | PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS CANNABINOID RECEPTOR ANTAGONISTS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-04-26 | — | — | WO | disclosed |