Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL209520 | 0.91 | AURKA (0.40) | AURKACHRM4 | |
| SCHEMBL16152489 | 0.88 | AURKA (0.38) | AURKAGBA1 | |
| SCHEMBL4789145 | 0.86 | CHRM4 (0.38) | AURKACHRM4AOC3IKBKBCHUK | |
| SCHEMBL210273 | 0.81 | AURKA (0.61) | AURKACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL208759 | 0.80 | CHEK2 (0.40) | AURKA | |
| SCHEMBL210746 | 0.79 | AURKA (0.41) | AURKA | |
| SCHEMBL210407 | 0.79 | AURKA (0.58) | AURKACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL209009 | 0.75 | AURKA (0.53) | AURKACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13985665 | 0.75 | MAP4K4 (0.40) | AURKA | |
| SCHEMBL13985591 | 0.74 | AURKA (0.43) | AURKACYP1A2CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001021-A1 | IMIDAZOPYRIDINE DERIVATIVES USEFUL AS ENZYME INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE AND AUTOIMMUNE DISEASES | CHROMA THERAPEUTICS LTD. (GB) | 2008-12-31 | — | — | WO | disclosed |