Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789897 | 0.86 | AURKA (0.42) | CHRM4AURKAAOC3IKBKBCHUK | |
| SCHEMBL209520 | 0.77 | AURKA (0.40) | CHRM4AURKAPRMT5CHEK2 | |
| SCHEMBL16152489 | 0.74 | AURKA (0.38) | AURKAPRMT5GBA1CHEK2 | |
| SCHEMBL210273 | 0.66 | AURKA (0.61) | AURKA | |
| SCHEMBL208759 | 0.66 | CHEK2 (0.40) | AURKAPRMT5CHEK2 | |
| SCHEMBL210407 | 0.65 | AURKA (0.58) | AURKAPRMT5 | |
| SCHEMBL29947171 | 0.64 | CHRM4 (0.46) | CHRM4AOC3LTA4HCHRNB2CHRNA4 | |
| SCHEMBL4756397 | 0.63 | DGAT1 (0.43) | AURKA | |
| SCHEMBL13985474 | 0.63 | AURKA (0.52) | AURKA | |
| SCHEMBL4757120 | 0.62 | CHRM4 (0.42) | CHRM4AOC3CHRNB2CHRNA4PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001021-A1 | IMIDAZOPYRIDINE DERIVATIVES USEFUL AS ENZYME INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE AND AUTOIMMUNE DISEASES | CHROMA THERAPEUTICS LTD. (GB) | 2008-12-31 | — | — | WO | claimed |