Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CDK7 | P50613 | 2/20 | 0.33 |
| ▸ | CCNH | P51946 | 2/20 | 0.33 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | PDE9A | O76083 | 3/20 | 0.32 |
| ▸ | ABL1 | P00519 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4724993 | 0.92 | MAPK8 (0.38) | HCAR1MAPK8MAPK9MAPK10MAPK14 | |
| SCHEMBL3052427 | 0.78 | MAPK8 (0.60) | MAPK8MAPK9MAPK10MAPK14CCNA2 | |
| SCHEMBL18865844 | 0.75 | TYRO3 (0.47) | KDM5BCDK7JAK2JAK1JAK3 | |
| SCHEMBL17910173 | 0.75 | RIPK2 (0.47) | HCAR1MAPK8MAPK9MAPK10MAPK14 | |
| SCHEMBL30556388 | 0.74 | MAPK8 (0.40) | MAPK8MAPK9MAPK10CCNA2CDK2 | |
| SCHEMBL16993087 | 0.73 | MAPK8 (0.55) | MAPK8MAPK9MAPK10MAPK14CCNA2 | |
| SCHEMBL30850695 | 0.73 | MAPK8 (0.42) | HCAR1MAPK8MAPK9MAPK10MAPK14 | |
| SCHEMBL29848596 | 0.72 | ACACB (0.39) | HCAR1MAPK8MAPK9MAPK10PDE9A | |
| SCHEMBL2011959 | 0.72 | XDH (0.39) | HCAR1MAPK8MAPK9MAPK10CCNA2 | |
| SCHEMBL30850747 | 0.70 | MAPK8 (0.42) | MAPK8MAPK9MAPK10MAPK14CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931667-A1 | PYRIDO-PYRIDIMIDINE DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS | Ranbaxy Laboratories Limited (IN) | 2008-06-18 | — | — | EP | claimed |
| WO-2007036791-A1 | PYRIDO-PYRIDIMIDINE DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS | RANBAXY LABORATORIES LIMITED (US) | 2007-04-05 | — | — | WO | claimed |