Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 16/20 | 0.45 |
| ▸ | XIAP | P98170 | 4/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702545 | 0.90 | RIPK1 (0.51) | RIPK1NR1I2CYP2C9 | |
| SCHEMBL14084908 | 0.89 | RIPK1 (0.49) | RIPK1XIAP | |
| SCHEMBL4705023 | 0.85 | RIPK1 (0.49) | RIPK1XIAPNR1I2CYP2C9 | |
| SCHEMBL14084905 | 0.79 | RIPK1 (0.61) | RIPK1 | |
| SCHEMBL14084910 | 0.79 | RIPK1 (0.57) | RIPK1XIAP | |
| SCHEMBL4701720 | 0.79 | BDKRB1 (0.39) | RIPK1XIAP | |
| SCHEMBL4704722 | 0.79 | CCKBR (0.53) | — | |
| SCHEMBL4701105 | 0.79 | CCKBR (0.40) | RIPK1CYP2C9 | |
| SCHEMBL4702034 | 0.78 | BDKRB1 (0.42) | CYP2C9 | |
| SCHEMBL4705804 | 0.77 | RIPK1 (0.37) | RIPK1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |