Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 19/20 | 0.69 |
| ▸ | CTSB | P07858 | 9/20 | 0.66 |
| ▸ | CTSS | P25774 | 5/20 | 0.66 |
| ▸ | CTSL | P07711 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8105820 | 0.89 | CTSK (0.57) | CTSKCTSBCTSS | |
| SCHEMBL4789905 | 0.89 | CTSK (0.57) | CTSKCTSBCTSS | |
| SCHEMBL4789866 | 0.84 | CTSK (0.70) | CTSKCTSBCTSSCTSL | |
| SCHEMBL8100014 | 0.82 | CTSK (0.60) | CTSKCTSBCTSS | |
| SCHEMBL2241411 | 0.82 | CTSK (1.00) | CTSKCTSBCTSS | |
| SCHEMBL2243628 | 0.82 | CTSK (1.00) | CTSKCTSBCTSS | |
| SCHEMBL4788694 | 0.81 | CTSK (0.67) | CTSKCTSBCTSS | |
| SCHEMBL8121853 | 0.81 | CTSK (0.67) | CTSKCTSBCTSS | |
| SCHEMBL8107252 | 0.81 | CTSK (0.67) | CTSKCTSBCTSS | |
| SCHEMBL8111299 | 0.81 | CTSK (0.67) | CTSKCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001128-A1 | 1,2-CYCL0HEXANE DICARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |