Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 6/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3905516 | 0.78 | MAPT (0.55) | MAPTKMT2ACES1KCNN4KCNH2 | |
| SCHEMBL7921071 | 0.72 | AHR (0.41) | MAPTKMT2ALMNAKDM4E | |
| SCHEMBL9416066 | 0.72 | KDM4E (0.43) | MAPTKMT2ATDP1CYP2D6CHRM2 | |
| SCHEMBL666600 | 0.69 | KMT2A (0.39) | MAPTKMT2ACES1 | |
| SCHEMBL10693506 | 0.69 | MAPT (0.52) | MAPTKMT2ACES1KCNN4KCNH2 | |
| SCHEMBL8283636 | 0.69 | MAPT (0.38) | MAPTKMT2A | |
| SCHEMBL28046683 | 0.68 | KCNN4 (0.32) | KMT2AKCNN4TSHR | |
| SCHEMBL340836 | 0.68 | KCNN4 (0.52) | MAPTKMT2ACES1KCNN4ALOX15 | |
| SCHEMBL9292143 | 0.67 | KCNN4 (0.48) | MAPTKMT2ACES1KCNN4TSHR | |
| SCHEMBL27529617 | 0.67 | KMT2A (0.35) | MAPTKMT2ACYP3A4ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966185-A2 | 2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR ß-SECRETASE MODULATION | Wyeth a Corporation of the State of Delaware (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007078813-A2 | 2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION | WYETH (US) | 2007-07-12 | — | — | WO | disclosed |