Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL671021 | 0.89 | AHR (0.43) | AHRMGAMMAPTKMT2ACNR2 | |
| SCHEMBL1695522 | 0.81 | CNR2 (0.40) | AHRMGAMKMT2ACNR2SSTR4 | |
| SCHEMBL3905516 | 0.78 | MAPT (0.55) | MAPTKMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL10694363 | 0.74 | MAPT (0.47) | MGAMMAPTKMT2ACNR2SSTR4 | |
| SCHEMBL4790426 | 0.72 | MAPT (0.39) | MAPTKMT2AKDM4ELMNA | |
| SCHEMBL25421647 | 0.72 | MGAM (0.46) | MGAMMAPTKMT2ACNR2SSTR4 | |
| SCHEMBL9564283 | 0.70 | ALDH1A1 (0.44) | KMT2AALDH1A1HPGDGAAKDM4E | |
| SCHEMBL30771873 | 0.70 | MGAM (0.47) | MGAMMAPTKMT2ACNR2SSTR4 | |
| SCHEMBL28623257 | 0.70 | MGAM (0.47) | MGAMMAPTKMT2ACNR2SSTR4 | |
| SCHEMBL17490348 | 0.69 | AHR (0.46) | AHRMGAMMAPTCNR2SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277833-B1 | 3-HYDROXY-3-METHYL-GLUTARYL COENZYME A (HGM--COA) REDUCTASE INHIBITORS WHICH RETARD CHOLESTEROL BIOSYNTHESIS | BAYER AKTIENGESELLSCHAFT (DE) | 2001-08-21 | — | — | US | disclosed |
| US-5861385-A | Substituted triols | BAYER AKTIENGESELLSCHAFT (DE) | 1999-01-19 | — | — | US | disclosed |