Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1906832 | 0.81 | ALDH1A1 (0.50) | GAAKDM4EHSD17B10ALDH1A1NPC1 | |
| SCHEMBL1950652 | 0.77 | BRD9 (0.42) | MAPTKMT2AMEN1LMNAMAPK10 | |
| SCHEMBL28006160 | 0.73 | MAPT (0.40) | MAPTKMT2AMEN1LMNAKDM4E | |
| SCHEMBL9041899 | 0.70 | KDM4E (0.62) | TSHRGAAMAPTKMT2AMEN1 | |
| SCHEMBL1949655 | 0.70 | KDM1A (0.48) | L3MBTL1HTTMETAP2 | |
| SCHEMBL7547745 | 0.70 | SMN1; SMN2 (0.71) | TSHRGAAMAPTKMT2AMEN1 | |
| SCHEMBL27144018 | 0.70 | TSHR (0.70) | TSHRGAAMAPTKMT2AMEN1 | |
| SCHEMBL28006058 | 0.69 | ALDH1A1 (0.36) | TSHRMAPTKMT2AMEN1LMNA | |
| SCHEMBL1905105 | 0.69 | LMNA (0.41) | LMNAKDM4EHSD17B10ALDH1A1L3MBTL1 | |
| SCHEMBL14818749 | 0.68 | TSHR (0.68) | TSHRGAAMAPTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966185-A2 | 2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR ß-SECRETASE MODULATION | Wyeth a Corporation of the State of Delaware (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007078813-A2 | 2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION | WYETH (US) | 2007-07-12 | — | — | WO | disclosed |