Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 1.00 |
| ▸ | VDR | P11473 | 5/20 | 0.81 |
| ▸ | USP2 | O75604 | 2/20 | 0.65 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.63 |
| ▸ | CASP7 | P55210 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.62 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | MDM4 | O15151 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.62 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.62 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16103960 | 1.00 | NR1H4 (1.00) | NR1H4VDRUSP2ABCC4CASP7 | |
| SCHEMBL8130893 | 0.91 | NR1H4 (1.00) | NR1H4VDRUSP2ABCC4CASP7 | |
| SCHEMBL8139937 | 0.90 | NR1H4 (1.00) | NR1H4VDRGPBAR1TDP1CYP3A4 | |
| SCHEMBL27719139 | 0.89 | VDR (1.00) | NR1H4VDRUSP2ABCC4CASP7 | |
| SCHEMBL1653677 | 0.89 | VDR (1.00) | NR1H4VDRUSP2ABCC4CASP7 | |
| SCHEMBL11410558 | 0.89 | NR1H4 (0.79) | NR1H4VDR | |
| SCHEMBL3391119 | 0.89 | NR1H4 (0.79) | NR1H4VDR | |
| SCHEMBL26642428 | 0.89 | NR1H4 (0.79) | NR1H4VDR | |
| SCHEMBL30653065 | 0.89 | NR1H4 (0.79) | NR1H4VDR | |
| SCHEMBL26642434 | 0.89 | NR1H4 (0.79) | NR1H4VDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2077855-B1 | THERAPEUTIC USE OF GBA2 | YILDIZ DR MED YILDIZ (DE) | 2012-02-01 | — | — | EP | disclosed |
| EP-2077855-A1 | THERAPEUTIC USE OF GBA2 | Rheinisch-Westfälisch-Technische Hochschule Aachen (DE) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008053025-A1 | THERAPEUTIC USE OF GBA2 | RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN (DE) | 2008-05-08 | — | — | WO | disclosed |