Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763232 | 0.90 | P2RX3 (0.62) | P2RX3 | |
| SCHEMBL4760984 | 0.82 | P2RX3 (0.61) | P2RX3 | |
| SCHEMBL4762047 | 0.68 | P2RX3 (0.69) | P2RX3 | |
| SCHEMBL25218655 | 0.67 | P2RX3 (1.00) | P2RX3 | |
| SCHEMBL4761800 | 0.67 | P2RX3 (1.00) | P2RX3 | |
| SCHEMBL4762256 | 0.65 | MEN1 (0.53) | — | |
| SCHEMBL9998699 | 0.65 | — | — | |
| SCHEMBL4763412 | 0.64 | PLK1 (0.51) | — | |
| SCHEMBL2356971 | 0.64 | P2RX3 (0.51) | P2RX3 | |
| SCHEMBL5462933 | 0.64 | P2RX3 (0.53) | P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917262-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007020194-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |