Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4791244 | 0.81 | MEN1 (0.50) | MEN1KMT2A | |
| SCHEMBL4761951 | 0.79 | PTGS2 (0.58) | PTGS2 | |
| SCHEMBL4501152 | 0.75 | POLB (0.57) | — | |
| SCHEMBL4486680 | 0.71 | KMT2A (1.00) | MEN1KMT2A | |
| SCHEMBL9998699 | 0.71 | — | — | |
| SCHEMBL4763412 | 0.69 | PLK1 (0.51) | — | |
| SCHEMBL4761953 | 0.67 | — | — | |
| SCHEMBL4791983 | 0.67 | ALDH1A1 (0.54) | — | |
| SCHEMBL10242916 | 0.67 | P2RX3 (0.50) | — | |
| SCHEMBL4790332 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917262-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007020194-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |