Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK2 | Q92630 | 17/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 15/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 15/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 14/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 5/20 | 0.53 |
| ▸ | CSNK2B | P67870 | 5/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.53 |
| ▸ | CSNK2A3 | Q8NEV1 | 5/20 | 0.53 |
| ▸ | PIM1 | P11309 | 8/20 | 0.53 |
| ▸ | CNR1 | P21554 | 3/20 | 0.48 |
| ▸ | CLK1 | P49759 | 2/20 | 0.44 |
| ▸ | CLK2 | P49760 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4127969 | 0.81 | ALOX5 (0.46) | — | |
| SCHEMBL4127964 | 0.81 | ALOX5 (0.46) | — | |
| SCHEMBL4792013 | 0.75 | HDAC4 (0.34) | — | |
| SCHEMBL4120717 | 0.70 | ALOX5 (0.41) | PIM1GSK3B | |
| SCHEMBL4120713 | 0.70 | ALOX5 (0.41) | PIM1GSK3B | |
| SCHEMBL6150323 | 0.68 | LTA4H (0.47) | — | |
| SCHEMBL23510744 | 0.68 | DYRK1A (0.77) | DYRK2DYRK1ADYRK1BDYRK3CSNK2A2 | |
| SCHEMBL29899849 | 0.68 | DYRK1A (0.77) | DYRK2DYRK1ADYRK1BDYRK3CSNK2A2 | |
| SCHEMBL28842954 | 0.68 | DYRK1A (0.77) | DYRK2DYRK1ADYRK1BDYRK3CSNK2A2 | |
| SCHEMBL29310479 | 0.66 | ALOX5 (0.80) | DYRK2DYRK1ADYRK1BDYRK3CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934192-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | Torrent Pharmaceuticals Ltd (IN) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007032028-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | TORRENT PHARMACEUTICALS LTD. (IN) | 2007-03-22 | — | — | WO | disclosed |