Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4566466 | 0.82 | RXFP1 (0.37) | NAMPTADAM17MMP1MMP9MMP13 | |
| SCHEMBL2472672 | 0.79 | NAMPT (0.43) | NAMPTCYP3A4MMP1MMP9MMP13 | |
| SCHEMBL1278509 | 0.77 | HTT (0.35) | PTGER4ELOVL6 | |
| SCHEMBL1580484 | 0.76 | CYP3A4 (0.39) | PTGER4NAMPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3910397 | 0.76 | DAGLA (0.40) | PTGER4NAMPTMMP9 | |
| SCHEMBL1278511 | 0.74 | DAGLA (0.38) | PTGER4ELOVL6 | |
| SCHEMBL1278507 | 0.74 | PTGER4 (0.38) | PTGER4CYP3A4CYP2C9CYP2C19ELOVL6 | |
| Fumaric Acid SCHEMBL1278437 | 0.74 | PTGER4 (0.39) | PTGER4NAMPTCYP3A4CYP2C9CYP2C19 | |
| Fumaric Acid SCHEMBL1278433 | 0.74 | PTGER4 (0.39) | PTGER4NAMPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3910404 | 0.73 | ALDH1A1 (0.41) | PTGER4NAMPTCYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919865-A1 | 1-HETEROCYCLYLSULFONYL, 2-AMINOMETHYL, 5- (HETERO-) ARYL SUBSTITUTED 1-H-PYRROLE DERIVATIVES AS ACID SECRETION INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026916-A1 | 1-HETEROCYCLYLSULFONYL, 2-AMINOMETHYL, 5- (HETERO-) ARYL SUBSTITUTED 1-H-PYRROLE DERIVATIVES AS ACID SECRETION INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-03-08 | — | — | WO | disclosed |