Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | PANK3 | Q9H999 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20251137 | 0.83 | MAPT (0.51) | MGLLMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL18596315 | 0.80 | MAPT (0.46) | MGLLMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL277165 | 0.79 | ALDH1A1 (0.54) | MGLLMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL18118174 | 0.79 | HPGD (0.52) | MGLLMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL847809 | 0.77 | ALDH1A1 (0.57) | MGLLMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL18118180 | 0.77 | ALDH1A1 (0.57) | MGLLMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL101926 | 0.76 | ALDH1A1 (0.64) | KMT2AL3MBTL1ALDH1A1MAPTMAPK1 | |
| SCHEMBL21610848 | 0.76 | MEN1 (0.46) | MGLLMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL2627852 | 0.76 | ALDH1A1 (0.67) | MEN1KMT2AL3MBTL1ALDH1A1MAPT | |
| SCHEMBL20258483 | 0.76 | ADRB1 (0.53) | MEN1KMT2AL3MBTL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332516-B2 | Geminally di-substituted NSAID derivatives as Aβ42 lowering agents | MERCK + CO., INC. (US) | 2008-02-19 | — | — | US | disclosed |
| WO-2008010061-A2 | 3-AZABICYCLO [3.1.0] HEXANE VANILLOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-01-24 | — | — | WO | disclosed |