Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4795408 | 0.89 | AURKA (0.49) | EGFRIGF1RAURKAAURKBALK | |
| SCHEMBL4796798 | 0.88 | EGFR (0.47) | EGFRGPR84AURKAMEN1KMT2A | |
| SCHEMBL4780654 | 0.81 | IGF1R (0.64) | EGFRIGF1RCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4780651 | 0.81 | IGF1R (0.64) | EGFRIGF1RCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4780646 | 0.81 | IGF1R (0.64) | EGFRIGF1RCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4780474 | 0.80 | EGFR (0.43) | EGFRGPR84IGF1RCYP1A2CYP3A4 | |
| SCHEMBL4782136 | 0.79 | MAPT (0.45) | IGF1RCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4780633 | 0.78 | AURKA (0.49) | EGFRGPR84IGF1RAURKAAURKB | |
| SCHEMBL4796341 | 0.77 | AURKA (0.45) | EGFRGPR84IGF1RAURKAAURKB | |
| SCHEMBL4781252 | 0.77 | KDM4E (0.52) | IGF1RCYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008025526-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | claimed |
| WO-2008025526-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | disclosed |