Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782136 | 0.91 | MAPT (0.45) | MEN1KMT2AMAPTKDM4ENPC1 | |
| SCHEMBL4781252 | 0.90 | KDM4E (0.52) | MEN1KMT2AMAPTKDM4ENPC1 | |
| SCHEMBL4792506 | 0.88 | EGFR (0.48) | EGFRMEN1KMT2AGPR84AURKA | |
| SCHEMBL4780474 | 0.83 | EGFR (0.43) | EGFRMEN1KMT2ACNR2GPR84 | |
| SCHEMBL4782089 | 0.82 | KDM4E (0.51) | MEN1KMT2AMAPTKDM4ENPC1 | |
| SCHEMBL4782147 | 0.80 | IGF1R (0.49) | MEN1KMT2AMAPTKDM4ENPC1 | |
| SCHEMBL4795187 | 0.78 | MAPT (0.43) | MEN1KMT2AMAPTKDM4ENPC1 | |
| SCHEMBL4795408 | 0.77 | AURKA (0.49) | EGFRMEN1KMT2AMAPTKDM4E | |
| SCHEMBL4780159 | 0.77 | KDM4E (0.45) | MEN1KMT2AMAPTKDM4ENPC1 | |
| SCHEMBL4781385 | 0.77 | MAPT (0.43) | MEN1KMT2AMAPTKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008025526-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | claimed |
| WO-2008025526-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | disclosed |