Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 16/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 15/20 | 0.66 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3526680 | 0.87 | KCNJ1 (0.87) | KCNJ1KCNH2HRH3SIGMAR1MAOA | |
| SCHEMBL2481337 | 0.82 | LMNA (0.71) | KCNJ1KCNH2 | |
| SCHEMBL2731306 | 0.81 | KCNJ1 (1.00) | KCNJ1KCNH2HRH3SIGMAR1MAOA | |
| SCHEMBL1509554 | 0.80 | LMNA (0.70) | KCNJ1KCNH2HRH3SIGMAR1 | |
| SCHEMBL5763269 | 0.77 | KCNJ1 (0.84) | KCNJ1KCNH2HRH3SIGMAR1MAOA | |
| SCHEMBL2723230 | 0.77 | KCNJ1 (0.84) | KCNJ1KCNH2HRH3SIGMAR1MAOA | |
| SCHEMBL5653299 | 0.75 | HRH3 (0.93) | KCNJ1KCNH2HRH3SIGMAR1MAOA | |
| SCHEMBL3156895 | 0.75 | HRH3 (1.00) | KCNJ1KCNH2HRH3SIGMAR1MAOA | |
| SCHEMBL77658 | 0.75 | TSHR (0.64) | KCNJ1KCNH2HRH3 | |
| SCHEMBL286800 | 0.74 | KCNJ1 (0.84) | KCNJ1KCNH2HRH3SIGMAR1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937681-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007033232-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |