Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CCR2 | P41597 | 1/20 | 0.52 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519334 | 0.93 | KDM4E (0.67) | LMNAKDM4EALDH1A1SMN1; SMN2KCNJ1 | |
| SCHEMBL55983 | 0.84 | LMNA (1.00) | LMNAKDM4EALDH1A1MAPTNPC1 | |
| SCHEMBL2482651 | 0.83 | KDM4E (0.56) | LMNAKDM4EALDH1A1SMN1; SMN2KCNJ1 | |
| Hydrochloric Acid SCHEMBL1675964 | 0.83 | LMNA (0.96) | LMNAKDM4EALDH1A1MAPTNPC1 | |
| SCHEMBL4792525 | 0.82 | KCNJ1 (0.66) | KCNJ1KCNH2 | |
| SCHEMBL374154 | 0.80 | KDM4E (0.67) | LMNAKDM4EALDH1A1SMN1; SMN2KCNJ1 | |
| SCHEMBL17805273 | 0.80 | KCNJ1 (0.68) | LMNAKDM4EALDH1A1SMN1; SMN2KCNJ1 | |
| SCHEMBL4565734 | 0.80 | ALDH1A1 (0.79) | LMNAKDM4EALDH1A1SMN1; SMN2KCNJ1 | |
| SCHEMBL3526680 | 0.79 | KCNJ1 (0.87) | KCNJ1KCNH2 | |
| SCHEMBL4849323 | 0.79 | SMN1; SMN2 (0.59) | LMNAKDM4EALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |