Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.42 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.42 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4792382 | 0.92 | SCN9A (0.62) | SCN9AL3MBTL1ELANEALDH1A1MAPT | |
| SCHEMBL4790806 | 0.86 | SCN9A (0.72) | SCN9AL3MBTL1ELANEALDH1A1ATM | |
| SCHEMBL4795265 | 0.86 | SCN9A (0.57) | SCN9AELANEALDH1A1GAAATM | |
| SCHEMBL4795594 | 0.85 | SCN9A (0.56) | SCN9AALDH1A1MAPTATMADORA1 | |
| SCHEMBL4791726 | 0.82 | SCN9A (0.55) | SCN9AELANETEAD1TEAD4TEAD2 | |
| SCHEMBL4795077 | 0.81 | SCN9A (0.57) | SCN9AL3MBTL1ELANEALDH1A1TEAD1 | |
| SCHEMBL4791493 | 0.81 | SCN9A (0.47) | SCN9AELANETEAD1TEAD4TEAD2 | |
| SCHEMBL4794092 | 0.79 | SCN9A (0.48) | SCN9AMAPTATMADORA1MAPK1 | |
| SCHEMBL12070101 | 0.77 | SCN9A (0.74) | SCN9AL3MBTL1ELANEALDH1A1MAPT | |
| SCHEMBL4794908 | 0.76 | TEAD1 (0.46) | SCN9AL3MBTL1ELANETEAD1TEAD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937647-A1 | CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II | Inpharmatica Limited (GB) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007036727-A1 | CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II | INPHARMATICA LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |
| WO-2007036727-A1 | CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II | INPHARMATICA LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |