Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.57 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.57 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.57 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.57 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ELANE | P08246 | 4/20 | 0.50 |
| ▸ | PLAU | P00749 | 3/20 | 0.50 |
| ▸ | F2 | P00734 | 2/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4791726 | 0.86 | SCN9A (0.55) | SCN9ATEAD1TEAD4TEAD2TEAD3 | |
| SCHEMBL717998 | 0.84 | ELANE (0.63) | SCN9AELANEPLAUF2TP53 | |
| SCHEMBL4792744 | 0.83 | L3MBTL1 (0.51) | TEAD1TEAD4TEAD2TEAD3L3MBTL1 | |
| SCHEMBL16260376 | 0.83 | SCN9A (0.56) | SCN9AELANEPLAUF2TP53 | |
| SCHEMBL14333217 | 0.82 | SCN9A (0.57) | SCN9AL3MBTL1ELANEPLAUF2 | |
| SCHEMBL4790822 | 0.82 | SCN9A (0.55) | SCN9AELANEPLAUF2ALDH1A1 | |
| SCHEMBL29005378 | 0.82 | TEAD1 (0.53) | SCN9ATEAD1TEAD4TEAD2TEAD3 | |
| SCHEMBL4792532 | 0.81 | SCN9A (0.61) | SCN9ATEAD1TEAD4TEAD2TEAD3 | |
| SCHEMBL14406104 | 0.81 | SCN9A (0.54) | SCN9AELANEPLAUF2TP53 | |
| SCHEMBL5945786 | 0.80 | SCN9A (0.62) | SCN9AELANEPLAUF2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937647-A1 | CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II | Inpharmatica Limited (GB) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007036727-A1 | CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II | INPHARMATICA LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |
| WO-2007036727-A1 | CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II | INPHARMATICA LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |