Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 10/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3289880 | 0.93 | CSF1R (0.56) | CSF1RMERTK | |
| SCHEMBL3293467 | 0.92 | CSF1R (0.49) | CSF1RKDM4EMERTKPDE4AKCNH2 | |
| SCHEMBL3289961 | 0.89 | POLB (0.49) | CSF1RKDM4EMERTKKMT2ANPC1 | |
| SCHEMBL11017743 | 0.88 | CSF1R (0.49) | CSF1RKDM4EPDE4AKCNH2 | |
| SCHEMBL4775328 | 0.85 | CSF1R (0.68) | CSF1R | |
| SCHEMBL28527127 | 0.83 | CSF1R (0.59) | CSF1RKDM4EPDE4AKCNH2RAB9A | |
| SCHEMBL4796017 | 0.81 | CSF1R (0.59) | CSF1RKDM4EMERTKKMT2ANPC1 | |
| SCHEMBL3293227 | 0.79 | CSF1R (0.56) | CSF1RMERTKPDE4AKCNH2KMT2A | |
| SCHEMBL3291712 | 0.79 | CSF1R (0.54) | CSF1RKDM4EMERTKPDE4AKCNH2 | |
| SCHEMBL4773699 | 0.79 | CSF1R (0.47) | CSF1RKDM4EMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945637-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-23 | — | — | EP | claimed |
| WO-2007033137-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | claimed |