Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 19/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1673975 | 0.81 | GPR119 (1.00) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL4793282 | 0.78 | GPR119 (0.66) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL29444725 | 0.74 | GPR119 (1.00) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL114213 | 0.74 | GPR119 (1.00) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL4557583 | 0.74 | GPR119 (0.72) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL27852838 | 0.74 | GPR119 (0.62) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL388948 | 0.72 | GPR119 (1.00) | GPR119 | |
| SCHEMBL15315330 | 0.71 | GPR119 (0.79) | GPR119CYP3A4CYP2C19CNR2 | |
| SCHEMBL1673848 | 0.71 | GPR119 (0.83) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL514572 | 0.71 | GPR119 (0.66) | GPR119CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1927594-A1 | 1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia | Arena Pharmaceuticals, Inc. (US) | 2008-06-04 | — | — | EP | claimed |