Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4770979 | 0.94 | MAPT (0.43) | MAPTPOLBLMNAMEN1KMT2A | |
| SCHEMBL4765151 | 0.81 | HRH3 (0.46) | HRH3HRH1NPC1SMN1; SMN2 | |
| SCHEMBL4765636 | 0.77 | HRH3 (0.48) | MAPTHRH3HRH1HSD17B10NPC1 | |
| SCHEMBL4771966 | 0.76 | NPC1 (0.40) | MAPTPOLBLMNAHRH3RET | |
| SCHEMBL5823896 | 0.76 | HRH3 (0.54) | MAPTLMNAKMT2AHRH3HRH1 | |
| SCHEMBL4770392 | 0.74 | HRH3 (0.59) | MAPTPOLBHRH3HRH1NPC1 | |
| SCHEMBL4765487 | 0.74 | HRH3 (0.50) | MAPTLMNAMEN1KMT2AHRH3 | |
| SCHEMBL4765404 | 0.74 | THRB (0.48) | MAPTPOLBLMNAHRH3HRH1 | |
| SCHEMBL4768220 | 0.73 | HRH3 (0.49) | MAPTLMNAHRH3HRH1NPC1 | |
| SCHEMBL4770985 | 0.73 | MAP4K1 (0.57) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |