Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 12/20 | 0.44 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4793722 | 0.88 | CSF1R (0.46) | CSF1RFLT3TLR7TLR9TLR8 | |
| SCHEMBL3530730 | 0.85 | CSF1R (0.63) | CSF1RINSRKITSRCFLT3 | |
| SCHEMBL3524814 | 0.77 | CSF1R (0.58) | CSF1RINSRKITSRCFLT3 | |
| SCHEMBL3531299 | 0.74 | CSF1R (0.75) | CSF1RINSRKITSRCFLT3 | |
| SCHEMBL3533550 | 0.71 | CSF1R (0.66) | CSF1RINSRKITSRCFLT3 | |
| SCHEMBL4775340 | 0.71 | CSF1R (0.48) | CSF1RKITSRCFLT3NTRK1 | |
| SCHEMBL4768393 | 0.70 | CSF1R (0.47) | CSF1RKITSRCFLT3NTRK1 | |
| SCHEMBL3530725 | 0.70 | CSF1R (0.66) | CSF1RINSRKITSRCFLT3 | |
| SCHEMBL4768934 | 0.70 | CSF1R (0.45) | CSF1RKITSRCFLT3NTRK1 | |
| SCHEMBL14196164 | 0.69 | CSF1R (0.72) | CSF1RINSRKITSRCFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937681-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007033232-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | claimed |