Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 3/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2563861 | 1.00 | AURKA (0.41) | AURKARAF1PDPK1AURKBFLT3 | |
| SCHEMBL479417 | 1.00 | AURKA (0.41) | AURKARAF1PDPK1AURKBFLT3 | |
| SCHEMBL3153364 | 0.93 | ALDH1A1 (0.43) | AURKBFLT3KMT2ACSF1RALDH1A1 | |
| SCHEMBL480621 | 0.93 | ALDH1A1 (0.43) | AURKBFLT3KMT2ACSF1RALDH1A1 | |
| SCHEMBL479748 | 0.87 | AURKA (0.41) | AURKARAF1PDPK1AURKBFLT3 | |
| SCHEMBL16752524 | 0.85 | AURKA (0.38) | AURKARAF1PDPK1AURKBFLT3 | |
| SCHEMBL16752525 | 0.85 | AURKA (0.38) | AURKARAF1PDPK1AURKBFLT3 | |
| SCHEMBL3675849 | 0.84 | AAK1 (0.56) | AURKARAF1PDPK1FLT3AAK1 | |
| SCHEMBL3675845 | 0.84 | AAK1 (0.56) | AURKARAF1PDPK1FLT3AAK1 | |
| SCHEMBL2121225 | 0.84 | PSEN1 (0.42) | AURKARAF1PDPK1AURKBFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411034-A1 | PROMOTION OF NEURONAL INTEGRATION IN NEURAL STEM CELL GRAFTS | Life & Brain GmbH (DE) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010108665-A1 | PROMOTION OF NEURONAL INTEGRATION IN NEURAL STEM CELL GRAFTS | LIFE & BRAIN GMBH (DE) | 2010-09-30 | — | — | WO | disclosed |