Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.36 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 3/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16752524 | 1.00 | AURKA (0.38) | AURKARAF1PDPK1AAK1FLT3 | |
| SCHEMBL3721672 | 0.95 | AURKA (0.37) | AURKARAF1PDPK1AAK1FLT3 | |
| SCHEMBL3721673 | 0.95 | AURKA (0.37) | AURKARAF1PDPK1AAK1FLT3 | |
| SCHEMBL479289 | 0.93 | RAB9A (0.39) | FLT3AURKBSENP1KMT2ACSF1R | |
| SCHEMBL479748 | 0.91 | AURKA (0.41) | AURKARAF1PDPK1AAK1FLT3 | |
| SCHEMBL479637 | 0.88 | RAB9A (0.38) | FLT3AURKBSENP1KMT2ACSF1R | |
| SCHEMBL479417 | 0.85 | AURKA (0.41) | AURKARAF1PDPK1AAK1FLT3 | |
| SCHEMBL479415 | 0.85 | AURKA (0.41) | AURKARAF1PDPK1AAK1FLT3 | |
| SCHEMBL2563861 | 0.85 | AURKA (0.41) | AURKARAF1PDPK1AAK1FLT3 | |
| SCHEMBL479768 | 0.85 | PSEN1 (0.40) | AURKARAF1PDPK1FLT3AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2878297-A1 | Medicaments for the treatment or prevention of fibrotic diseases | Boehringer Ingelheim International GmbH (DE) | 2015-06-03 | — | — | EP | disclosed |