Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 2/20 | 0.58 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.58 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.58 |
| ▸ | HRH1 | P35367 | 3/20 | 0.53 |
| ▸ | SLC5A7 | Q9GZV3 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4934208 | 0.86 | SLC5A7 (0.54) | HRH1SLC5A7ALDH1A1MEN1KMT2A | |
| SCHEMBL22130619 | 0.83 | SLC5A7 (0.55) | HRH1SLC5A7MEN1KMT2AOPRK1 | |
| SCHEMBL4930039 | 0.82 | MAPK14 (0.58) | SLC5A7HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL4666647 | 0.82 | SLC5A7 (0.54) | SCN1ASCN2ASCN3ASLC5A7RAB9A | |
| SCHEMBL4933296 | 0.81 | SLC5A7 (0.60) | SLC5A7RAB9AMEN1KMT2AOPRK1 | |
| SCHEMBL4933614 | 0.80 | LMNA (0.53) | SLC5A7MEN1KMT2ALMNAKDM1A | |
| SCHEMBL14026961 | 0.79 | SLC5A7 (0.54) | SLC5A7HPGDALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4664680 | 0.78 | SLC5A7 (0.53) | SLC5A7HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL14026963 | 0.78 | LMNA (0.64) | SLC5A7RAB9AHPGDMEN1KMT2A | |
| SCHEMBL4235922 | 0.77 | HIF1A (0.47) | SLC5A7KDM4EMEN1KMT2AOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891065-A1 | NOVEL MCHR1 ANTAGONISTS AND THEIR USE FOR THE TREATMENT OF MCHR1 MEDIATED CONDITIONS AND DISORDERS | AstraZeneca AB (SE) | 2008-02-27 | — | — | EP | claimed |
| WO-2006130075-A1 | NOVEL MCHR1 ANTAGONISTS AND THEIR USE FOR THE TREATMENT OF MCHR1 MEDIATED CONDITIONS AND DISORDERS | ASTRAZENECA AB (SE) | 2006-12-07 | — | — | WO | claimed |