Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.51 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.51 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.51 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.47 |
| ▸ | KHK | P50053 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4112896 | 0.86 | PIM1 (0.51) | PIM1PIM3PIM2MAP4K1KHK | |
| SCHEMBL4795298 | 0.83 | HTR7 (0.51) | ALDH1A1HPGDADRB1HTR3AKDM4E | |
| SCHEMBL4106851 | 0.74 | MAPT (0.55) | PIM1MAP4K1ALDH1A1HPGDKDM4E | |
| SCHEMBL12324749 | 0.72 | KDM4E (0.72) | PIM1PIM3PIM2CETPALDH1A1 | |
| SCHEMBL4110029 | 0.72 | ATR (0.53) | ALDH1A1HPGDHIF1AACVR1CYP1A2 | |
| SCHEMBL4112835 | 0.72 | PIM1 (0.45) | PIM1PIM3PIM2MAP4K1KHK | |
| SCHEMBL4101654 | 0.71 | ATR (0.53) | KDM4EHIF1AS1PR2LMNAKMT2A | |
| SCHEMBL1359864 | 0.71 | ADRB1 (0.76) | PIM1PIM3PIM2KHKCETP | |
| SCHEMBL4112507 | 0.70 | MAP4K1 (0.47) | MAP4K1ALDH1A1KDM4ENPC1MAPT | |
| SCHEMBL4112890 | 0.70 | HTR7 (0.51) | ALDH1A1HPGDADRB1KDM4EHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009076-A2 | SUBSTITUTED PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | disclosed |