Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | KIF11 | P52732 | 5/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27856324 | 0.86 | MAPT (0.40) | MAPTKMT2ACYP2C19HIF1ACYP2D6 | |
| SCHEMBL3083611 | 0.81 | KMT2A (0.43) | MAPTKMT2ACYP2C19HIF1ACYP2D6 | |
| SCHEMBL4055699 | 0.78 | CYP2C19 (0.50) | MAPTKMT2ACYP2C19HIF1ACYP2D6 | |
| SCHEMBL17064282 | 0.76 | MAPT (0.44) | MAPTKMT2ACYP2C19HIF1ACYP2D6 | |
| SCHEMBL5898545 | 0.74 | MAPT (0.43) | MAPTKMT2ACYP2C19HIF1ACYP2D6 | |
| SCHEMBL5365607 | 0.74 | MAPT (0.46) | MAPTKMT2ACYP2C19HIF1ACYP2D6 | |
| SCHEMBL23042785 | 0.73 | MAPT (0.35) | MAPTKMT2ACYP2C19HIF1ACYP2D6 | |
| SCHEMBL4058267 | 0.73 | CYP2C19 (0.49) | MAPTKMT2ACYP2C19HIF1ACYP2D6 | |
| SCHEMBL11249 | 0.73 | MAPT (0.42) | MAPTKMT2ACYP2C19HIF1ACYP2D6 | |
| SCHEMBL27654137 | 0.73 | CYP2C19 (0.41) | KMT2ACYP2C19HIF1ACYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008016676-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-02-07 | — | — | WO | disclosed |