Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 4/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8360630 | 0.83 | MAPT (0.43) | MAPTKMT2ACYP2C19CYP1A2CYP2C9 | |
| SCHEMBL8363513 | 0.83 | KCNN4 (0.49) | KCNN4KDM4E | |
| SCHEMBL5898567 | 0.83 | ALDH1A1 (0.38) | KMT2ACYP2C19CYP1A2CYP2C9KIF11 | |
| SCHEMBL6266034 | 0.83 | CES2 (0.39) | KMT2ACYP2C19CYP1A2KIF11LMNA | |
| SCHEMBL5898588 | 0.82 | MAPT (0.46) | MAPTKMT2ACYP2C19CYP1A2CYP2C9 | |
| SCHEMBL17594854 | 0.81 | CYP1A2 (0.61) | MAPTKMT2ACYP2C19CYP1A2CYP2C9 | |
| SCHEMBL17064282 | 0.81 | MAPT (0.44) | MAPTKMT2ACYP2C19CYP1A2CHRM3 | |
| SCHEMBL4055699 | 0.79 | CYP2C19 (0.50) | MAPTKMT2ACYP2C19CYP1A2CHRM3 | |
| SCHEMBL23014014 | 0.77 | CYP2C19 (0.48) | KMT2ACYP2C19CYP1A2CYP2C9CHRM3 | |
| SCHEMBL4307361 | 0.77 | CYP2C19 (0.56) | KMT2ACYP2C19CYP1A2CYP2C9CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230414566-A1 | ARYL-SUBSTITUTED ACETAMIDE AND PYRROLIDIN-2-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SEIZURES | UNIVERSITY OF HOUSTON SYSTEM (US) | 2023-12-28 | — | — | US | disclosed |
| US-11806333-B2 | Aryl-substituted acetamide and pyrrolidin-2-one derivatives and their use for the treatment of seizures | UNIVERSITY OF HOUSTON SYSTEM (US) | 2023-11-07 | — | — | US | disclosed |
| US-20200360342-A1 | ARYL-SUBSTITUTED ACETAMIDE AND PYRROLIDIN-2-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SEIZURES | UNIVERSITY OF HOUSTON SYSTEM (US) | 2020-11-19 | — | — | US | disclosed |
| US-20060287397-A1 | Dl-hydroxy-alkyl-phenylamides having anticonvulsive activity | MEZA TOLEDO SERGIO E | 2006-12-21 | — | — | US | disclosed |
| US-5463125-A | 3-hydroxy-3-phenylpentamide | SANDOVAL GUILLERMO C (MX) | 1995-10-31 | — | — | US | disclosed |
| US-5463125-A | 3-hydroxy-3-phenylpentamide | SANDOVAL GUILLERMO C (MX) | 1995-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200360342-A1 | ARYL-SUBSTITUTED ACETAMIDE AND PYRROLIDIN-2-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SEIZURES | AADAC, GABRB2, GABARAPL2 | MAPT 1500/4885KMT2A 1290/4885CYP2C19 148/4885 |
| US-20060287397-A1 | Dl-hydroxy-alkyl-phenylamides having anticonvulsive activity | GABRB2, HRH3, HRH4 | MAPT 2331/4885KMT2A 211/4885CYP2C19 1452/4885 |
| US-20230414566-A1 | ARYL-SUBSTITUTED ACETAMIDE AND PYRROLIDIN-2-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SEIZURES | AADAC, GABRB2, GABARAPL2 | MAPT 1500/4885KMT2A 1290/4885CYP2C19 148/4885 |
| US-11806333-B2 | Aryl-substituted acetamide and pyrrolidin-2-one derivatives and their use for the treatment of seizures | AADAC, GABRB2, GABARAPL2 | MAPT 1500/4885KMT2A 1290/4885CYP2C19 148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.