Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16713397 | 0.77 | CYP2D6 (0.49) | KIF11CYP2D6CYP1A2MAPTKMT2A | |
| SCHEMBL3838081 | 0.76 | KIF11 (0.49) | KIF11CYP2D6CYP1A2MAPTKMT2A | |
| SCHEMBL27510805 | 0.75 | SCN5A (0.41) | KIF11CYP2D6CYP1A2MAPTKMT2A | |
| SCHEMBL4058270 | 0.74 | KIF11 (0.48) | KIF11CYP2D6CYP1A2MAPTKMT2A | |
| SCHEMBL28033810 | 0.72 | MAPT (0.47) | KIF11CYP2D6CYP1A2MAPTKMT2A | |
| SCHEMBL27783915 | 0.71 | CYP2D6 (0.55) | KIF11CYP2D6CYP1A2MAPTKMT2A | |
| Propane SCHEMBL28558464 | 0.71 | MAPT (0.50) | KIF11CYP2D6CYP1A2MAPTKMT2A | |
| SCHEMBL5365607 | 0.71 | MAPT (0.46) | KIF11CYP2D6CYP1A2MAPTKMT2A | |
| SCHEMBL4782888 | 0.71 | CYP2D6 (0.42) | KIF11CYP2D6CYP1A2MAPTKMT2A | |
| SCHEMBL2283147 | 0.70 | MAPT (0.48) | KIF11CYP2D6CYP1A2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008016676-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-02-07 | — | — | WO | disclosed |