Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.52 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | ITK | Q08881 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL758975 | 0.83 | ROCK2 (0.61) | ROCK2ROCK1AURKACA12CA9 | |
| SCHEMBL10269652 | 0.78 | NAMPT (0.70) | ROCK2ROCK1AURKACA12CA9 | |
| SCHEMBL627856 | 0.77 | TRPV1 (0.55) | ROCK2ROCK1GSK3BMAPK1MMP3 | |
| SCHEMBL14404250 | 0.76 | ITK (0.60) | ROCK2ROCK1AURKACA12CA9 | |
| SCHEMBL11888642 | 0.75 | MAPT (0.66) | ROCK2ROCK1CA12CA9RAB9A | |
| SCHEMBL17117402 | 0.75 | CA12 (0.69) | ROCK2ROCK1CA12CA9RAB9A | |
| SCHEMBL20804368 | 0.74 | NPC1 (0.65) | ROCK2ROCK1CA12CA9RAB9A | |
| SCHEMBL5639950 | 0.74 | CASP3 (0.68) | ROCK2ROCK1CA12CA9RAB9A | |
| SCHEMBL5660604 | 0.73 | NAMPT (0.79) | ROCK2ROCK1RAB9AIMPDH2PTPN7 | |
| SCHEMBL20772904 | 0.73 | CA12 (0.62) | ROCK2ROCK1CA12CA9RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001480-A2 | INDAZOLE COMPOUNDS | Abbott Laboratories (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007117465-A2 | INDAZOLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-10-18 | — | — | WO | disclosed |