Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 12/20 | 0.62 |
| ▸ | BRD4 | O60885 | 6/20 | 0.62 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.60 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.60 |
| ▸ | PLK2 | Q9NYY3 | 3/20 | 0.60 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.60 |
| ▸ | PDXK | O00764 | 1/20 | 0.60 |
| ▸ | WEE1 | P30291 | 1/20 | 0.60 |
| ▸ | NEK3 | P51956 | 1/20 | 0.60 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.60 |
| ▸ | MAPK7 | Q13164 | 5/20 | 0.55 |
| ▸ | DCLK1 | O15075 | 4/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | NEK4 | P51957 | 1/20 | 0.49 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4796469 | 1.00 | PLK1 (0.62) | PLK1BRD4PTK2PLK3PLK2 | |
| SCHEMBL4801607 | 0.90 | PLK1 (0.60) | PLK1BRD4PTK2PLK3PLK2 | |
| SCHEMBL4801615 | 0.90 | PLK1 (0.60) | PLK1BRD4PTK2PLK3PLK2 | |
| SCHEMBL14180611 | 0.89 | PLK1 (0.60) | PLK1BRD4PTK2PLK3PLK2 | |
| SCHEMBL4798805 | 0.87 | PLK1 (0.60) | PLK1BRD4PTK2PLK3PLK2 | |
| SCHEMBL4798796 | 0.87 | PLK1 (0.60) | PLK1BRD4PTK2PLK3PLK2 | |
| SCHEMBL4800822 | 0.83 | PLK1 (0.63) | PLK1BRD4PTK2PLK3PLK2 | |
| SCHEMBL4800835 | 0.83 | PLK1 (0.63) | PLK1BRD4PTK2PLK3PLK2 | |
| SCHEMBL24782031 | 0.82 | PLK1 (0.71) | PLK1BRD4PTK2PLK3PLK2 | |
| SCHEMBL12323787 | 0.80 | PLK1 (0.78) | PLK1BRD4PTK2PLK3PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371753-B2 | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-05-13 | — | — | US | disclosed |
| US-20060046990-A1 | New dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060046990-A1 | New dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions | QDPR, DHPS, CCND2 | PLK1 3122/4885BRD4 4057/4885PTK2 4470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.