Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21396196 | 0.84 | LRRK2 (0.42) | ADRA2AHTR7ADRA1AADRA2BADRA2C | |
| SCHEMBL12223407 | 0.84 | ADRA2A (0.51) | ADRA2ATDP1ADRA2BADRA2CMAOA | |
| SCHEMBL27922809 | 0.81 | ADRA2A (0.45) | ADRA2ATDP1ADRA2BADRA2CMAOA | |
| SCHEMBL16429614 | 0.80 | HNF4A (0.44) | ADRA2ATDP1ADRA2BADRA2CMAOA | |
| SCHEMBL11806943 | 0.80 | TDP1 (0.44) | TDP1ALDH1A1LMNACYP3A4L3MBTL1 | |
| SCHEMBL19018371 | 0.79 | CD274 (0.50) | ADRA2AHTR7ADRA1ACD274PDCD1 | |
| SCHEMBL6344376 | 0.76 | DPP4 (0.42) | ADRA2ATDP1ADRA2BADRA2CMAOA | |
| SCHEMBL6343690 | 0.76 | CD274 (0.42) | ADRA2ACD274TDP1ADRA2BADRA2C | |
| SCHEMBL25785668 | 0.75 | PDCD1 (0.64) | ADRA2AHTR7ADRA1ACD274PDCD1 | |
| SCHEMBL22888632 | 0.74 | ADRA2A (0.47) | ADRA2AHTR7ADRA1ACD274PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033455-A2 | BIPHENYL AND HETEROARYL PHENYL DERIVATIVES AS PROTEIN TYROSINE PHOSPHATASES INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |