Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4288671 | 0.86 | CYP3A4 (0.68) | ALDH1A1TSHRHSD17B10CYP3A4CTSD | |
| SCHEMBL27266429 | 0.85 | CYP3A4 (0.58) | ALDH1A1TSHRHSD17B10CYP3A4CTSD | |
| SCHEMBL8788585 | 0.85 | CYP3A4 (0.58) | ALDH1A1TSHRHSD17B10CYP3A4CTSD | |
| SCHEMBL11757412 | 0.85 | CYP3A4 (0.58) | ALDH1A1TSHRHSD17B10CYP3A4CTSD | |
| SCHEMBL8041829 | 0.84 | CYP3A4 (0.73) | ALDH1A1TSHRHSD17B10CYP3A4LMNA | |
| SCHEMBL11767742 | 0.84 | CYP3A4 (0.56) | ALDH1A1TSHRHSD17B10CYP3A4RAB9A | |
| SCHEMBL2983592 | 0.84 | CYP3A4 (0.56) | ALDH1A1TSHRHSD17B10CYP3A4CTSD | |
| SCHEMBL8788034 | 0.83 | CYP3A4 (0.55) | ALDH1A1TSHRHSD17B10CYP3A4CTSD | |
| SCHEMBL4728649 | 0.82 | ALDH1A1 (0.54) | ALDH1A1TSHRHSD17B10CTSDRAB9A | |
| SCHEMBL1399045 | 0.82 | CYP3A4 (0.54) | ALDH1A1TSHRHSD17B10CYP3A4CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008012852-A1 | INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF ANGIOTENSIN II ANTAGONISTS | S.I.M.S. S.r.l. - SOCIETÀ ITALIANA MEDICINALI SCANDICCI (IT) | 2008-01-31 | — | — | WO | claimed |
| EP-1778650-A1 | PROCESS FOR PREPARING CANDESARTAN CILEXETIL | Dr. Reddy's Laboratories Ltd. (IN) | 2007-05-02 | — | — | EP | claimed |
| WO-2006015134-A1 | PROCESS FOR PREPARING CANDESARTAN CILEXETIL | DR. REDDY'S LABORATORIES LTD. (IN) | 2006-02-09 | — | — | WO | claimed |
| WO-2008012852-A1 | INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF ANGIOTENSIN II ANTAGONISTS | S.I.M.S. S.r.l. - SOCIETÀ ITALIANA MEDICINALI SCANDICCI (IT) | 2008-01-31 | — | — | WO | disclosed |
| EP-1778650-A1 | PROCESS FOR PREPARING CANDESARTAN CILEXETIL | Dr. Reddy's Laboratories Ltd. (IN) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006015134-A1 | PROCESS FOR PREPARING CANDESARTAN CILEXETIL | DR. REDDY'S LABORATORIES LTD. (IN) | 2006-02-09 | — | — | WO | disclosed |